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Covance Expands Drug Metabolism Services

Adds drug-transporter interactions with eight human transporters

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Covance has expanded its drug metabolism services to include drug-transporter interactions with eight human transporters. The company now offers assessment of drug-transporter interactions involving major human transporters key to drug disposition in a stably transfected, cell-based format.

“For more than 30 years, Covance has helped our clients achieve a detailed understanding of the disposition of their drug candidates,” said Jon Denissen, Ph.D., vice president of Global Drug Metabolism. “The addition of drug-transporter interactions to our service offering enables our clients to define the importance of transporters in their drug discovery and development programs, select the best drug candidates, and meet the latest expectations of regulatory agencies.”

The eight cell lines in the drug-transporter interactions service include P-glycoprotein (P-gp/MDR1), breast cancer resistant protein (BCRP), organic cation transporters 1& 2 (OCT1 & OCT2), organic anion transporter 3 (OAT3), organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1 & OATP1B3), and multidrug resistance-associated protein 2 (MRP2).

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